Mizuno took up professional modelling at age 20 with Profile Models in London. She has modelled for
Chanel,
Alexander McQueen,
Saint Laurent, and
Louis Vuitton. While modeling, she took acting classes and made her film debut in 2014, in
Alex Garland's science-fiction
thriller Ex Machina, In 2017, Mizuno appeared in a small role as the debutante in Disney's live-action adaptation of
Beauty and the Beast, and in 2018, she acted in the
Warner Bros. film
Crazy Rich Asians. She has appeared in television/streaming roles including
Cary Joji Fukunaga's
Maniac on Netflix. In 2018, she took the lead role of Lily Chan in Garland's miniseries for
FX,
Devs. In 2024, she appeared in the war drama
Civil War. She has worked with Garland five times: as the lead of
Devs, as a supporting character in
Ex Machina and
Civil War, and as a featured extra in
Annihilation and
Men. Mizuno appeared on stage in Gareth Farr’s
A Child of Science, which ran at the
Bristol Old Vic from June to July 2024. ==Filmography==