SC 120 begins at an
intersection with
SC 261 (West Fulton Street) in Pinewood within
Sumter County, where the roadway continues as West Avenue South. It travels to the north-northeast and travels along the eastern edge of
Manchester State Forest and the
Poinsett Electronic Combat Range and occasionally cuts through small segments of the forest. Just south of
Tuomey Wildlife Management Area, it curves to the northeast. It passes through parts of Sumter before entering the
census designated place of
Millwood. Upon leaving Millwood, the highway re-enters Sumter and immediately intersects
SC 763 (Wedgefield Road), next to Millwood Elementary School. The two highways travel
concurrently to the northeast. At Alice Drive, SC 120 splits off to the north-northwest. It passes Alice Drive Elementary School, which is just southwest of the
University of South Carolina Sumter campus. At South Wise Drive, the highway passes Palmetto Park. It begins to curve to the north and meets its eastern terminus, an intersection with
U.S. Route 76 (US 76)/
US 378 (Broad Street). Here, Alice Drive curves to the northeast to an intersection with
US 521 (Camden Highway). ==Major intersections==