SC 146's western terminus is at Laurens Road (
U.S. Route 276 or US 276), near the intersection of Interstates
85 (I-85) and
385. Its course then goes in a southeasterly direction where its eastern terminus is at its intersection with
SC 56 near Cross Anchor. From its western terminus to its split from
SC 417, SC 146 is known as Woodruff Road. From its split to the merger with
SC 101, SC 146 is known as 3rd Street. Once SC 146/SC 101 merges with
US 221 in Woodruff it is known as Main Street, then Laurens Road as it splits from SC 101. Its final name change happens when SC 146 splits from US 221 just outside Woodruff; its name changes to Cross Anchor Highway, and it keeps that name until it reaches its eastern terminus. ==Major intersections==