SC 213 begins at an
intersection with
U.S. Route 176 (US 176) southeast of
Pomaria within Newberry County, where the roadway continues as Parr Road. It travels to the east and crosses over Crims Creek. A short distance later, the highway crosses over the
Broad River, Hampton Island and some
railroad tracks on an unnamed bridge. This bridge marks the Fairfield County line. SC 213 travels to the northeast and intersects
SC 215 (Monticello Road) near Jenkinsville. The two highways travel
concurrently along the southeastern edge of the
Monticello Reservoir. They split, with SC 213 traveling to the east. A short distance later, it curves to the northeast and then crosses over Little River. Farther to the northeast is a crossing of Robinson Branch. It skirts along the southwestern edge of the
city limits of
Winnsboro. After a short rural section, it meets its eastern terminus, an intersection with
US 321/
SC 34 just southwest of
Winnsboro Mills. This intersection also marks the southern terminus of
US 321 Business (Columbia Road). ==Major intersections==