The first SC 24 was an original state highway, which operated as a spur from
SC 12 in
Hibernia, to
Ninety Six. By 1926, SC 24 was extended southeast on new primary routing through
Pelion to
SC 6 in
North. In 1928, SC 24 was extended south, from North, to
SC 64 in
Olar. In 1929, SC 24 was extended west, in concurrency with
US 25 to
Hodges, then replacing
SC 25 to
Donalds, and
SC 15 to
SC 2 in
Clemson. That same year, SC 24 was rerouted to avoid Ninety Six, with its former route becoming
SC 246. By 1930, SC 24 was rerouted at North, replacing SC 6 to Orangeburg then in concurrency with SC 2, through
Bowman and
Rosinville, to
US 78. In 1931, SC 24 was extended west along SC 2, through
Seneca and
Walhalla, then solo through
Mountain Rest to the Georgia state line; SC 24 reached its longest at approximately . In 1933, US 178 replaced SC 24 between Anderson and US 78; SC 24 remained west of Anderson to Georgia. In 1938, SC 24 was renumbered as part of
SC 28. The second and current SC 24 was established in 1938 as a renumbering of
SC 18, between Westminster and Anderson. By 1964, SC 24 eastern terminus changed from Market and Main Streets to Whitier and Main Streets, coinciding with the elimination of
SC 80. ==Major intersections==