SC 263 begins at an
intersection with
SC 764 (Main Street) in Eastover, Richland County. It travels to the northeast and leaves the
city limits. The highway crosses Griffin Creek. Approximately later, it intersects
U.S. Route 601 (US 601; McCords Ferry Road). Farther to the northeast, it meets its northern terminus, an intersection with
US 76/
US 378 (Garners Ferry Road). ==Major intersections==