SC 414 begins at an
intersection with
U.S. Route 276 (US 276; Geer Highway) south of
Marietta, within Greenville County. It travels to the north-northeast and curves to the northeast and crosses Bull Creek. The highway curves to the east-southeast and has a very brief
concurrency with
US 25. SC 414 travels to the northeast and crosses over Mush and Johnson creeks. It travels through
North Greenville University in
Tigerville. On the southeastern edge of the university is an intersection with the northern terminus of
SC 253 (Mountain View Road). SC 414 crosses over the South Tyger River. Then, it heads in a more easterly direction and crosses Tyger Cemetery. The highway enters
Highland, where it has a very brief concurrency with
SC 101. It curves to the east and passes Ebenezer Cemetery just before heading to the southeast. It curves back to the east just before meeting its eastern terminus, an intersection with
SC 14. ==Major intersections==