SC 53 begins at an
intersection with
US 378 (Myrtle Beach Highway) southwest of
Shiloh, within
Sumter County. It travels to the northeast, through
rural areas of the county, and curves to a nearly due east direction. It intersects
SC 58 (Pleasant Grove Road), and the two highways begin a
concurrency. They have an
interchange with
Interstate 95 (I-95), where they enter Shiloh. Approximately later, SC 53 splits off to the south, onto Pudding Swamp Road. SC 53 continues through rural areas of the county to an intersection with
SC 341 (Mt. Zion Road). About later is the highway's northern terminus, an intersection with
SC 403 (Lynches River Road/Amwell Church Road). This is southwest of the
Lynches River. ==Major intersections==