South Central Conference may refer to:South Central Athletic Conference, college athletic conference of historically black colleges and universities (HBCUs) from 1935 to 1961 South Central Conference (California), junior college athletic conference in California formed in 1948 South Central Conference (Illinois), high school athletic conference in Illinois formed in 1926 South Central Conference (Indiana), high school athletic conference in Indiana from 1936 to 1997 South Central Conference (Iowa), high school athletic conference in Iowa formed in 1930 South Central Conference (Minnesota), high school athletic conference formed in 2024, largely from former Minnesota River Conference member schools