Funds for its establishment were provided by a centenary hospital appeal by the Sisters of Charity for St Vincent's Hospital. Helen Mills, the largest donor, asked for the centre to be named after her father
James Patrick Garvan, a distinguished New South Wales parliamentarian and business leader. The Kinghorn Cancer Centre, a 100 million joint venture between Garvan and St Vincent's Hospital, was opened on 28 August 2012 by Prime Minister
Julia Gillard. The centre is named after the Kinghorn Foundation, one of the centre's main benefactors. In 2014, the institute became one of only three organisations in the world able to sequence the
human genome at a base cost below 1,000 each (the
$1,000 genome) when it purchased the next generation of genome-sequencing equipment, which is capable of sequencing 350 genomes a week (18,000 a year).
Professor Chris Goodnow, internationally renowned immunologist, became Executive Director in 2018. He oversaw the development of rapid and affordable genome sequencing and the growing application of personalised medicine. In 2023, Prof Benjamin Kile, an internationally recognised and highly regarded blood cell molecular biologist, was appointed Executive Director. Kile has refined the Institute’s strategic focus to genomics, immunology and cancer. ==Research==