South San Antonio High School is a public high school located in the city of San Antonio, Texas, United States and classified as a 5A school by the UIL. It is a part of the South San Antonio Independent School District located in southwest Bexar County. South San Antonio High School opened in a new building on August 26, 2013. For the 2024-2025 school year, the school was given a "D" by the Texas Education Agency.