This frog is up to long. Males at sexual maturity average snout to vent length and females average SVL. It is green or brown in color with a yellowish ridge along each side of the back. Rounded dark spots occur on the back and sides; a light spot is seen on each
tympanum. The male has larger fore limbs than the female. The breeding male's vocal sacs are spherical when inflated. The call is described as a "ratchet-like trill", "chuckling croak", or a "squeaky balloon-like sound". The
larva is mottled, and the eyes are positioned on the top of the head. It grows to in length before maturing. The female lays an egg mass that is "baseball-sized" when close to hatching time, and contains up to 1,500 eggs. It is possible to confuse this species for the similarly shaped and colored
pickerel Frog (
Lithobates palustris). However, pickerel frogs dark spots along their back are more rectangular, uniform, and form rows. The spot in the center of their tympanum, if present, is a dark green/brown rather than a stark white. Southern Leopard Frogs may also be confused with the
Atlantic Coast Leopard Frog (Lithobates kauffeldi) in the northern portion of its range. Where both species occur, it may be impossible to confidently distinguish the two. However, Southern Leopard Frogs have a lighter femoral reticulum (inner thigh), more elongate snout, and light spot on the tympanum. == Ecology and behavior ==