Potency In Brazil, scorpions are credited with causing the highest incidence of human envenomations of all venomous animals. They cause more than all other venomous animals, including snakes and spiders, combined. With mortality rates ranging from 1.0 to 2.0% among children and elderly persons,
T. serrulatus is responsible for more medically significant accidents than any other scorpion in the country. Most stings occur in urban areas, inside or near homes, with greater frequency in the south and southeast during the warm and rainy months, but with little or no seasonal variability in the north, northeast, and center-west.
Effects In mild cases, localized pain is the primary symptom.
Tityus serrulatus venom contains
TsIV, which slows the inactivation of
sodium channels in muscles and nerve cells.
Tityus serrulatus has an excitatory
neurotoxin that attacks the autonomic nervous system, causing the release of adrenaline, noradrenaline and acetylcholine, causing an immense variety of symptoms in the victims; clinical effects may include
hyperglycemia, fever,
priapism, agitation,
hypersalivation,
tachycardia,
hypertension,
mydriasis,
sweating,
hyperthermia, tremors, gastrointestinal complications (
diarrhea,
abdominal pain,
nausea,
vomiting) and
pancreatitis.
Convulsions and
coma are relatively rare, but can occur. Death usually results from
pulmonary edema and
cardiorespiratory failure. Deaths can occur between 1–6 hours, or 12–14 hours, depending on the age group, the person's state of health and the quantity of injected venom. The venom of this species seems to have different lethalities according to its distribution,
T. serrulatus from
Distrito Federal has an
LD50 of 51.6 μg/kg, compared to LD50 from
T. serrulatus from
Minas Gerais, 26 μg/kg. According to a nationwide epidemiological study of scorpion accidents that was conducted from 2000 to 2012, there were 482,616 accidents and 728 deaths reported in Brazil during that period. All of the fatal cases were attributed to the genus
Tityus, and
T. serrulatus, in particular, was believed to be responsible for the vast majority of scorpion-related deaths considered by the study. ==References==