Hartington became increasingly uneasy with Gladstone's Irish policies, especially after the
murder of his younger brother Lord Frederick Cavendish in Phoenix Park. After being elected in December 1885 for the newly created
Rossendale Division of Lancashire, he broke with Gladstone altogether. He declined to serve in Gladstone's
third government, formed after Gladstone came out in favour of
Irish Home Rule (unlike Joseph Chamberlain, who accepted the Local Government Board but then resigned), and after opposing the
First Home Rule Bill became the leader of the Liberal Unionists. After the
general election of 1886 Hartington declined to become Prime Minister, preferring instead to hold the balance of power in the House of Commons and give support from the back benches to the second Conservative government of Lord Salisbury. Early in 1887, after the resignation of
Lord Randolph Churchill, Salisbury offered to step down and serve in a government under Hartington, who now declined the premiership for the third time. Instead, the Liberal Unionist
George Goschen accepted the Exchequer in Churchill's place. Having succeeded as
Duke of Devonshire in 1891 he entered the House of Lords where, in 1893, he formally moved for the rejection of the
Second Home Rule Bill. Devonshire eventually joined Salisbury's third government in 1895 as
Lord President of the Council, and from March 1900 was also
President of the Board of Education. Devonshire was not asked to become Prime Minister when
Lord Salisbury retired in favour of his nephew
Arthur Balfour in 1902. He resigned from the government in 1903, and from the Liberal Unionist Association the following spring, in protest at
Joseph Chamberlain's
Tariff Reform scheme. Devonshire said of Chamberlain's proposals: I venture to express the opinion that [Chamberlain] will find among the projects and plans which he will be called upon to discuss none containing a more Socialistic principle than that which is embodied in his own scheme, which, whether it can properly be described as a scheme of protection or not, is certainly a scheme under which the State is to undertake to regulate the course of commerce and of industry, and tell us where we are to buy, where we are to sell, what commodities we are to manufacture at home, and what we may continue, if we think right, to import from other countries. Balfour, trying to juggle different factions, had allowed both Chamberlain and Free Trade supporters to resign from the government, hoping that Devonshire would remain for the sake of balance, but the latter eventually resigned under pressure from
Charles Thomson Ritchie and from his wife, who still hoped that he might lead a government including leading Liberals. But in the autumn of 1907 his health gave way, and grave symptoms of cardiac weakness necessitated his abstaining from public effort and spending the winter abroad. He died, rather suddenly of pneumonia in his home after falling ill on his vacation to Cannes, on 24 March 1908. ==Military service==