Spermacoce prostrata is a species of plants in the Rubiaceae. In the United States, it is widespread in Florida, with a few isolated populations in Alabama and Mississippi. The species is native to Mexico, Central America, the Caribbean (Bahamas, Cuba, Hispaniola, Puerto Rico, Trinidad, Turks & Caicos, the Lesser Antilles, and the Dutch and Venezuelan Antilles. It is also widespread in South America, found in every country except Chile. The species is reportedly naturalized in Hawaii, China, Japan, Taiwan, Sri Lanka, Thailand and Java.