Outcast teen genius
Peter Parker develops spider-like superhuman abilities after being bitten by a genetically altered spider. He learns to use his newfound powers in an optional tutorial, narrated by
Bruce Campbell. Peter then uses his powers for personal gain and enters a
wrestling competition; however, the fight promoter cheats him out of his prize money. The promoter is then robbed by a
robber, whom Peter lets go out of spite. Shortly afterward, Peter is devastated when his
Uncle Ben is killed by a robber, whom the police identify as the leader of the Skulls gang. Peter tracks down and defeats the murderer at a warehouse where he is hiding from the police, only to discover that he is the same robber he let go earlier, who then dies after accidentally slipping out of a window. Remembering Ben's words that "
with great power comes great responsibility," Peter vows to use his powers to fight evil and becomes the masked
superhero Spider-Man. He also gets a job at the
Daily Bugle as a photographer after selling photos of himself as Spider-Man. Meanwhile, Oscorp CEO
Norman Osborn and his scientists are investigating the appearance of this new hero. Anxious to develop his Human Performance Enhancer "Super Soldier" serum, the main goals of which are already exhibited by Spider-Man, Osborn sends robots to capture him, but Spider-Man destroys them. Later, Spider-Man witnesses the
Shocker and the
Vulture robbing a jewelry store and escaping separately. Pursuing Shocker first, Spider-Man pursues him through the sewers and into a subway station, where he defeats him. Not wanting to let the Vulture get away with his share of the loot, Shocker tells Spider-Man that he is hiding in an old clock tower. Spider-Man climbs the tower, but the Vulture attempts to escape. After a chase through the city, Spider-Man finally defeats Vulture on top of the
Chrysler Building and leaves him and the stolen loot for the police to find. Later, Oscorp creates several
spider-shaped robots to capture Spider-Man. Still, they end up pursuing
Scorpion instead, whom they had mistaken for Spider-Man due to him also having
arachnid DNA. After returning to the subway station to take photos of his battle site with Shocker, Spider-Man runs into Scorpion and helps him fight off the spider bots. However, an increasingly paranoid Scorpion then attacks Spider-Man, believing he is trying to take him back to the scientists who experimented on him. Scorpion is defeated but manages to escape. Meanwhile, Osborn was fired from Oscorp for failing to complete the super-soldier serum on time. He decides to test it on himself, creating a psychopathic alternate personality: the
Green Goblin. Sporting experimental armor, a glider, and an arsenal of advanced weapons, he attacks the yearly Oscorp Unity Day Festival to kill those who fired him. Peter's friend and crush,
Mary Jane Watson, is caught in the chaos, but Peter intervenes as Spider-Man and rescues her. Grateful, she kisses him as a spider bot photographs them from afar. Spider-Man then fights the Goblin, stopping him from harming more bystanders. Impressed, the Goblin offers Spider-Man a chance to join him, but the latter refuses. The Goblin then reveals he has planted bombs filled with deadly gas all over the city and escapes while Spider-Man finds and disarms the bombs. In the
Xbox version only, Osborn later hires
Kraven the Hunter to capture Spider-Man. Luring him to a zoo, Kraven poisons him and forces him to complete an obstacle course filled with deadly traps while hunting him. Ultimately, Spider-Man defeats Kraven and leaves him for the police, obtaining an antidote for the poison. After another battle with the Goblin, Spider-Man studies a piece of the villain's gear that he recovered and learns that Oscorp manufactured it. Infiltrating the Oscorp building to investigate further, he avoids detection by the security. He makes his way to the secret labs, where he discovers chemical weapons and a giant robot being made, and he neutralizes both. Spider-Man then arrives in Osborn's office and learns that the Goblin knows about Mary Jane after seeing the photograph of her kissing him. Deducing that the Goblin kidnapped Mary Jane to lure him out, Spider-Man escapes from Oscorp and chases the Goblin to the
Queensboro Bridge, where he rescues Mary Jane and defeats the villain. The Goblin unmasks himself as Osborn and accidentally gets impaled by his glider in a final attempt to kill Spider-Man. Before he dies, Osborn asks Spider-Man not to reveal his identity as the Goblin to his son
Harry. Spider-Man attempts to reveal his identity to Mary Jane, but stops when she kisses him. Spider-Man then ends the game with a
fourth wall break, telling the player to "go outside and play." == Development ==