The most common parameters measured in spirometry are vital capacity (VC), forced vital capacity (FVC), forced expiratory volume (FEV) at timed intervals of 0.5, 1.0 (FEV1), 2.0, and 3.0 seconds, forced expiratory flow 25–75% (FEF 25–75) and maximal voluntary ventilation (MVV), also known as Maximum breathing capacity. Other tests may be performed in certain situations. Results are usually given in both raw data (litres, litres per second) and percent predicted—the test result as a percent of the "predicted values" for the patients of similar characteristics (height, age, sex, and sometimes race and weight). The interpretation of the results can vary depending on the physician and the source of the predicted values. Generally speaking, results nearest to 100% predicted are the most normal, and results over 80% are often considered normal. Multiple publications of predicted values have been published and may be calculated based on age, sex, weight and ethnicity. However, review by a doctor is necessary for accurate diagnosis of any individual situation. A bronchodilator is also given in certain circumstances and a pre/post graph comparison is done to assess the effectiveness of the bronchodilator. See the example printout.
Functional residual capacity (FRC) cannot be measured via spirometry, but it can be measured with a
plethysmograph or dilution tests (for example, helium dilution test).
Forced vital capacity (FVC) Forced
vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration, measured in liters. FVC is the most basic maneuver in spirometry tests.
Forced expiratory volume in 1 second (FEV1) FEV1 is the volume of air that can forcibly be blown out in first 1-second, after full inspiration. Predicted normal values for FEV1 can be calculated and depend on age, sex, height, mass and ethnicity as well as the research study that they are based on.
FEV1/FVC ratio FEV1/FVC is the ratio of FEV1 to FVC. In healthy adults this should be approximately 70–80% (declining with age). In obstructive diseases (asthma, COPD, chronic bronchitis, emphysema) FEV1 is diminished because of increased airway resistance to expiratory flow; the FVC may be decreased as well, due to the premature closure of airway in expiration, just not in the same proportion as FEV1 (for instance, both FEV1 and FVC are reduced, but the former is more affected because of the increased airway resistance). This generates a reduced value ( Maximum voluntary ventilation (MVV) is a measure of the maximum amount of air that can be inhaled and exhaled within one minute. For the comfort of the patient this is done over a 15-second time period before being extrapolated to a value for one minute expressed as liters/minute. Average values for males and females are 140–180 and 80–120 liters per minute respectively.
Static lung compliance (Cst) When estimating static lung compliance, volume measurements by the spirometer needs to be complemented by
pressure transducers in order to simultaneously measure the
transpulmonary pressure. When having drawn a curve with the relations between changes in volume to changes in transpulmonary pressure, Cst is the slope of the curve during any given volume, or, mathematically, ΔV/ΔP. Static lung compliance is perhaps the most sensitive parameter for the detection of abnormal pulmonary mechanics. It is considered normal if it is 60% to 140% of the average value in the population for any person of similar age, sex and body composition.
Others Forced Expiratory Time (FET) Forced Expiratory Time (FET) measures the length of the expiration in seconds.
Slow vital capacity (SVC) Slow
vital capacity (SVC) is the maximum volume of air that can be exhaled slowly after slow maximum inhalation.
Maximal pressure (Pmax and
Pi) Pmax is the asymptotically maximal pressure that can be developed by the respiratory muscles at any lung volume and Pi is the maximum inspiratory pressure that can be developed at specific lung volumes. This measurement also requires pressure transducers in addition. It is considered normal if it is 60% to 140% of the average value in the population for any person of similar age, sex and body composition.
Maximal inspiratory pressure (MIP) MIP, also known as
negative inspiratory force (NIF), is the maximum pressure that can be generated against an occluded airway beginning at functional residual capacity (FRC). It is a marker of respiratory muscle function and strength. Represented by centimeters of water pressure (cmH2O) and measured with a
manometer. Maximum inspiratory pressure is an important and noninvasive index of
diaphragm strength and an independent tool for diagnosing many illnesses. Typical maximum inspiratory pressures in adult males can be estimated from the equation, MIP = 142 - (1.03 x Age) cmH2O, where age is in years. ==Technologies used in spirometers==