Spyridon was Archbishop of Athens and All Greece from 1949 until 1956. He was born in Chili (Χήλη), in present-day northern Turkey. His parents originated from the village of Roupsia, near Pogoni in northern Greece. He studied at the Halki seminary. As a senior preacher in Kavala, he offered moral and material support to the Struggle for Macedonia, and in 1906, he was elected Metropolitan Bishop of Vella and Konitsa. His services during the Balkan Wars and on the matter of Northern Epirus were significant. In the Vella Monastery, he founded a seminary based on a primary school.