This gene encodes a ubiquitously expressed
transcription factor that controls
cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (
bHLH-Zip) domain. Various
single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee
osteoarthritis. == Interactions ==