The
ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of
actin dynamics. ADF/cofilin
proteins are inactivated by
kinases such as LIM domain kinase-1 (
LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM] == References ==