Archaeological investigations indicate that the island has been inhabited for at least 5,000 years.
David Hurst Thomas states that the initial inhabitants settled first in the most productive areas of the Pleistocene core of the island. The population steadily increased until well after arrival of Europeans in the 16th century. While the increased population required more intensive exploitation of the resources of the island and surrounding waters, which would be expected to lead to overexploitation, Thomas observes that the
white-tailed deer population remained viable on the island, with
venison remaining an important part of the islanders' diet throughout. Fish and shellfish were also important components of their diet. As of 2022, excavation of an approximately 4,000-year-old human grave site on St. Catherines Island is spearheaded by
David Hurst Thomas and Matthew C. Sanger. Excavations at the grave site, which is surrounded by a large ring of seashells known as the McQueen
shell ring, have uncovered copper objects closely corresponding to those found at hunter-gatherer sites in the Great Lakes region, suggesting that traders may have travelled all the way from the Midwest to St Catherines Island. Thomas has directed systematic Spanish period mission excavations on St. Catherines Island for decades. These indicate that there were two stages of occupation (1587–1597, and 1604–ca. 1650) by Spanish missions on the island. They have revealed the remains of the churches,
conventos (friars' quarters), a kitchen, wells, the churchyard, and part of the Indian settlement attached to the mission.
Kathleen Deagan writes, "The work has provided detailed information about early Franciscan mission architecture and building construction, organization of space, diet, material culture, and economic strategies." A cemetery (
campo santo) was found inside the remains of the church of Santa Catalina de Guale, where at least 431 persons were buried beneath the floor. It contained an assortment of associated
grave goods, including crosses, Franciscan medallions, small medals, Jesuit finger rings, a cast figurine of the infant Jesus, and other religious and utilitarian objects. There was a
Guale settlement on St. Catherines Island by 1576, and it was established as the northernmost permanent Spanish outpost on the
Atlantic Coast in 1587. Spanish colonies were planted as far north as
Chesapeake Bay, but none lasted more than a year or two. During the 17th century, the mission of
Santa Catalina de Guale, located on the island from 1602 to 1680, was the center of the Guale missionary province of
Spanish Florida. When English raiders from Charles Town,
Carolina, attacked the mission in 1680, Captain Francisco de Fuentes rallied his Spanish soldiers and Guale musketeers to defend the mission, but they were overwhelmed by the English. He also established a militia that worked to keep white people off the island. In the autumn of 1865, after the
United States Congress repealed Sherman's Orders,
African-American Union soldiers were sent to evict Campbell from his island, as he would not fire upon other blacks. Subsequently, Jacob Waldburg, following his pardon issued by President Andrew Johnson on 29 August 1865, reclaimed the island and plantation he owned prior to the civil war. The
1893 Sea Islands Hurricane caused catastrophic destruction, sweeping seawater across the entire island. Only one person who remained on it during the storm survived, and all buildings were destroyed. In 1943,
Edward John Noble bought the island, and used it to raise
Angus cattle. They are habituated to humans and roam freely. St. Catherines Island was declared a
National Historic Landmark and automatically placed on the
National Register of Historic Places in 1969. ==See also==