Saint Charles was founded in June 1832 by
Francis Kenrick,
Bishop of Philadelphia, in his home on Fifth Street. At that time, all of the dioceses in the United States needed more American-born priests to serve the growing Catholic immigrant population. In the beginning, the only faculty members at Saint Charles were Francis Kenrick and his brother, Reverend
Peter Kenrick. Francis Kenrick later moved Saint Charles to three buildings on the site of a former church in the city. In April 1838, Saint Charles was chartered by the
Commonwealth of Pennsylvania to grant
academic degrees as a
major seminary. In January 1839, Kenrick moved the seminary to a three-story building at 18th and Race Streets in Philadelphia. From 1841 to 1852, the
Vincentian Order ran the seminary. In the early 1850s,
John Neumann established a
minor seminary program for Saint Charles in
Glen Riddle, Pennsylvania. This program provided high school courses and two years of college to boys wanting to enter the priesthood. In 1863,
James F. Wood purchased three properties in Overbrook to create a new Saint Charles campus. Philadelphia had just experienced a
tuberculosis outbreak and he felt that a rural setting would be safer for the seminarians. In September 1871, Wood moved the minor and major seminaries to Overbrook. The total enrollment at that time was 128 students. In December 1875, Wood dedicated the Chapel of the Immaculate Conception on the campus. In 2019, the archdiocese sold its Wynnewood property to
Main Line Health. In May 2024, workers moved the historic white cross on the Wynnewood campus to the Malvern Retreat House. It was initially erected in honor of John Paul II's 1979 visit to Philadelphia. Saint Charles moved in August 2024 to its new campus adjacent to
Gwynedd Mercy University in Ambler. On September 8, 2024,
Nelson J. Pérez, Archbishop of Philadelphia, dedicated the Chapel of the Immaculate Conception on the new campus. On October 12, 2024, Pérez blessed and dedicated the campus.
Christophe Pierre, apostolic nuncio to the United States, spoke during the ceremony. Pérez in January 2025 announced that Christopher Redcay would become the next rector of Saint Charles in July 2025. ==Academics==