St. Dominic's has topped the A-Level league table of schools in Northern Ireland with over 95% of entrants receiving 3 or more A-levels at Grades A* to C. In 2019, the school was placed 2nd out of 159 secondary schools in Northern Ireland in its A-Level performance with 94.5% entrants in the 2017–18 academic year receiving this level. In 2021, 98.5 per cent of pupils achieved grades A* to C in three subjects at A Level. Of these A-level students, 69 per cent of grades achieved were A* or A and 92 per cent were A* to B. In the 2018
Belfast Telegraph GCSE League Table, it was ranked joint ninth in Northern Ireland for its GCSE performance with 99.3% of its entrants to the exam in 2016–17 receiving five or more GCSEs at grades A* to C, including the core subjects English and Maths. In the 2019 League Table it was ranked joint sixth with 99.4% of its GCSE exam entrants receiving five or more A* to C grades. The school is a
specialist school for
humanities. Since 2022, St. Dominic's has collaborated with
Friends' School, Lisburn in the development of a Shared Education Signature Project. The primary focus of the project has been creating a ‘Shared History’ based around the events of 1916. history departments in both schools felt that a more ‘joined-up’ approach to the teaching of the
Battle of the Somme and the
Easter Rising was necessary. ==Sports and extra-curricular activities==