In 1882, the American priests of the
Congregation of Holy Cross took over the Vicariate of East Bengal from the Benedictine Fathers. At the time, Mr. and Mrs. Wise — who were Protestants — ran a school in the present Wiseghat area near the
River Buriganga. In this school, most of the students were of European or Anglo-Indian Catholic communities. Anglican and Baptist pastors were allowed to teach religion at this school. Father Francis Boers, CSC, made numerous efforts to be a teacher of
Catholic Religion to the Catholic students at the school, but was not allowed. Out of frustration, he started an English-medium school on the grounds of the present adjoining St. Francis Xavier's Convent and girls' high school, that came into being later. The renamed St. Gregory's School shifted to the present site in 1896. == Headmasters ==