In 1860 Edward Strutt offered to sell the house to the governors of
Derby School. Initially the school could not afford to buy the house, but Edward Strutt, "being desirous of promoting the cause of education in Derby" loaned the house for free, on a temporary basis. The school moved to the house in January 1861 and purchased it from Strutt in 1863, for £3,300. £1,300 of this came from a public subscription and £2,000 from a mortgage raised by Derby Corporation. During
World War II the school was evacuated and the buildings were occupied by the
Ordnance Survey organisation to undertake the creation of maps used by Allied Forces. In this period the school was housed first at Overton Hall,
Ashover (September 1939 – June 1940) and secondly at Amber Valley Camp at
Woolley Moor (June 1940 until July 1945). The school returned to St Helen's House in September 1945. Derby School moved from St Helen's House in 1966 when it moved to a new purpose-built complex in
Littleover called Moorway Lane. Following this move St Helen's House was used as the Joseph Wright School of Art and, from 1972, as an Adult Education centre. Due to the deterioration of the external fabric of the buildings, the centre was moved and the building became vacant in 2004. ==Sale, subsequent conversion and development of site==