The school opened with grades 7-8 in August 1993. Its high school division opened in 1999. With its first graduating class in 2002, its high school division was the newest high school in the
Roman Catholic Diocese of Little Rock. The final building, on of land, was developed from a fundraising program that began in 1999, and resulted in a campus completed in 2000. The party that arranged to have the building established was the Pine Bluff Educational Endowment (PBEE), which leased its building to St. Joseph; PBEE had requested that its property host a Catholic school. Originally the St. Joseph Church subsidized and managed the school. By May 2012 the church was less able to give subsidies, so the
Roman Catholic Diocese of Little Rock Office of Catholic Schools took over management duties. The school was going to close in 2012 but Anthony B. Taylor, the bishop of the diocese, gave a clemency of one year. Taylor did so after the community raised $38,505 as part of the "Save St. Joseph School" campaign. Alexandra Pritchett became the principal in 2012. John Worthen of the
Pine Bluff Commercial wrote that area Catholic schools were losing students as many who wanted private education came to Ridgway Christian instead. The school was the last Catholic school remaining in the county. ==Student body and staff==