The school's roots go back to 1876 when St. Mary's Institute was opened with a handful of female pupils, many from local Irish families. During the next 50 years, the school underwent several transformations. By
World War I it was a co-ed school. At one time, the school building at 1200 Main Street included a grade school, but by the 1960s, when enrollment swelled, the building was used solely as a high school. Marinette Catholic Central High School, now part of the St. Thomas Aquinas system of Catholic day schools, was founded in 1958, when the four Marinette parishes of St. Joseph, Sacred Heart, St. Anthony, and Our Lady of Lourdes, assumed joint control of the former Our Lady of Lourdes High School. The school consists of an elementary program (pre-K-5th) at its campus in Peshtigo and 6th-12th at the main campus in Marinette. ==Extra-curricular activities==