State Highway 288 was designated on September 26, 1939 as the renumbering of the portion of State Highway 19 south of downtown Houston. On August 1, 1962, SH 288 was extended to
FM 1495. On June 25, 1981, SH 288 was rerouted from I-45 to MacGregor Way in Houston on the new freeway. The original routing ran southward along Almeda Road in Houston. The route traveled southward through
Fresno, past the
Houston Southwest Airport, before reaching
Bonney. This entire portion of the route from US 90 Alt. southward was transferred to
Farm to Market Road 521 and
Spur 300 on December 14, 1981, as SH 288 was rerouted onto the new freeway from US 90 Alt. to Spur 300. The route then traveled east through downtown Angleton, continuing southeast before reaching Freeport. This original section is now part of County Road 543 and
Farm to Market Road 523. SH 288 was redirected southward from Angleton when the city of Clute became more populated, then continued southward to a new intersection with State Highway 36 west of Freeport. On November 18, 1983, SH 288 was rerouted on the new freeway from MacGregor Way to US 90 Alt. The entire remaining section from FM 521 north of Angleton to Clute was transferred first to Texas State Highway 227 on September 26, 1986, and later Business Highway 288 on October 25, 1990 when the bypass around the western side of Lake Jackson opened. The section from Clute south to Freeport was transferred to SH 227, and the section concurrent with SH 36 became SH 36 on February 23, 1989. On August 15, 1989, SH 288 was extended south over part of SH 227 and concurrent with SH 36, restoring the lost section from Clute to Freeport. ==Major intersections==