SR 350 starts in Osgood at the corner of Buckeye Street and Beech Street. Buckeye Street runs northwest–southeast carrying
U.S. Route 421, and Beech Street runs northeasterly from here carrying SR 350. The highway passes through residential neighborhoods, before leaving Osgood. After leaving Osgood the road turns more east–west passing through rural Ripley County. The highway enters the
community of
Delaware and has an intersection with
SR 129. After SR 129 the road becomes southeast–northwest and heads towards
Pierceville. In Pierceville the road parallels a
CSX Transportation rail track, passing a few residential properties. East of Pierceville SR 350 turns towards the east leaves the rail track and passes through rural Ripley County for a short distance before entering the town of
Milan. The highway passes through the northern part of Milan and an intersection with
SR 101. After Milan the road turns towards the southeast and passes north of
Moores Hill, before passing through rural Dearborn County. While in rural Dearborn County the road passes near
Sparta,
Mount Sinai, and just north of
Wilmington. East of Wilmington SR 350 passes
South Dearborn High School, before entering Aurora. In Aurora the roadway crosses over the south fork of the Hogan Creek. The SR 350 designation ends at an intersection with US 50 crossing northeast–southwest and SR 56 continuing towards the southeast. ==History==