This species is found mostly in
Mexico, mainly in
Sonora and southern
Baja California and Northern Sinaloa. It is also known to the United States, but is much rarer, with the notable exception of
Organ Pipe Cactus National Monument. The plant is predominantly found on rocky hillsides up to in elevation. It is sensitive to frost, so the species is rare in low desert areas, which can be more susceptible to frost. The plant is slow growing, and prefers well-drained
soil and full sun. File:Stenocereus thurberi kz01.jpg|
Stenocereus thurberi in Tillotson Peak Wayside in Organ Pipe Cactus Wilderness, Arizona File:Glandulicereus thurberi (5769184920).jpg|Adult plant growing in
Guamuchil, Sinaloa File:Glandulicereus thurberi (5782823382).jpg|Habitat in Viscaino, Baja California Sur File:Large Organ Pipe Cactus And Brittlebush Flowers Ajo Mountain Drive Organ Pipe Cactus National Monu (137310847).jpeg|Plant growing in habitat along with
Encelia farinosa in Ajo Mountain drive, Organ Pipe Cactus National Monument ==Taxonomy==