Grasshopper Lichtsteiner made his first team debut with
Grasshopper Zürich during the
2001–02 season in the former Nationalliga A (now the
Swiss Super League) but only made one league appearance. The following season, he began to establish himself as a first team regular and helped the club to the league title.
Lazio After some good performances at
UEFA Euro 2008, several clubs, including
Paris Saint-Germain and
Everton, expressed interest in signing Lichtsteiner. He rejected PSG's bid and, in July, signed a four-year contract with Italian side
S.S. Lazio for an undisclosed fee believed to be in the region of €1.5 million as a replacement for fellow Swiss international
Valon Behrami, who went to
West Ham United. In the April
Derby della Capitale against cross-city rivals
Roma, he scored his first goal to put Lazio 3–1 up in a heated derby encounter, which ended in a 4–2 win to Lazio, and resulted in numerous bookings. Lichtsteiner himself was also booked for a heated confrontation with Roma defender
Christian Panucci, after the Italian had fouled him. During the season, Lichtsteiner formed an attacking tandem down the flanks with Serbian international full-back
Aleksandar Kolarov on the other side of the pitch. Although Lazio finished tenth, they ended the season on a high by winning the
Coppa Italia, and thus earning a place in the
UEFA Europa League the next season. He played a part in Lazio's successful campaign, scoring in the penalty shoot-out against
Sampdoria in the
final, and also claimed the
Supercoppa Italiana at the beginning of the next season. After Kolarov's departure, his future at Lazio became increasingly in doubt, as several clubs expressed interest in him. At the end of the 2010–11 season, he opted not to see out the final year of his contract, despite the
Biancocelesti qualifying for the Europa League.
Juventus On 27 June 2011,
Juventus confirmed that Lichtsteiner had undergone a medical in
Turin and reached an agreement with Lazio to pay €10 million in three installments. The transfer was confirmed on 1 July 2011. He marked his debut on 11 September 2011 against
Parma by scoring the first goal in the 4–1 home victory, the first league goal to be scored in Juventus' new
stadium. Juventus went on to win the
Scudetto and he played a vital part in their strong defensive record, only missing a handful of matches through injury and suspensions. Lichtsteiner repeated his opening matchday feat the following season by converting his left-sided counterpart
Kwadwo Asamoah's pass in the 2–0 win. He played fewer matches during
2013–14 season due to injuries but contributed three goals in all competitions and won his third consecutive
Serie A title. His
crossing and ball-playing ability from the right flank, as well as his ability to make attacking runs to get on the end of
Andrea Pirlo's long passes, came to the fore as a right-sided wing-back in
Antonio Conte's
3–5–2 formation. As a result, he finished the season as Juventus's top assist-maker in the league, alongside
Paul Pogba, with eight. On 6 June 2015, Lichtsteiner started for Juventus in the
2015 UEFA Champions League Final as the team were defeated 3–1 by
Barcelona at Berlin's
Olympiastadion; he was involved in
Álvaro Morata's temporary equalising goal. On 23 September 2015, Lichtsteiner was substituted at half time during a league match against
Frosinone due to breathing difficulty. It was later necessary for heart surgery to be performed to correct
cardiac arrhythmia, which caused him to be out for a month. On 3 November 2015, Lichtsteiner returned from injury, starting against
Borussia Mönchengladbach in the
2015–16 Champions League and scoring the equalizing goal in the 44th minute of a 1–1 away draw which was later voted one of the best goals of the tournament that season. At the beginning of the 2016–17 season, Lichtsteiner was excluded from Juventus's squad for the
UEFA Champions League group stage; this was due to the fact that the club had signed rightback
Dani Alves, and had already filled their squad quota, as Juventus were also required to have four club youth products in the 25-men squad, even though initially the only former youth product in the first team was
Claudio Marchisio. Thus, Lichtsteiner was excluded to make way for other players. Juventus had also re-signed
Juan Cuadrado on loan, which meant that Lichsteiner would face competition for the starting right fullback/wingback/winger position, leading to rumours that he would be leaving the club; nevertheless, he later stated that he would be remaining with Juventus. Despite competition for a starting spot, Lichtsteiner took part in the
2016 Supercoppa Italiana on 23 December 2016, as one of the starting eleven, as Juventus lost to
AC Milan on penalties. On 2 February 2017, Lichsteiner renewed his contract until 30 June 2018. On 1 September, Licthsteiner was not included in the Juventus's squad for the
UEFA Champions League group stage again. On 9 September, Licthsteiner played his first match as team's
captain in a 3–0 win against
Chievo. On 7 March 2018, Lichtsteiner made his 250th appearance for Juventus in a 2–1 win over
Tottenham at
Wembley Stadium, in the second leg of the round of 16 of the
UEFA Champions League, coming off the bench in the second half to help create
Gonzalo Higuaín's goal. He made his 200th Serie A appearance with the club in a 3–1 home win over
Bologna on 5 May, after which he announced that he would be leaving the club at the end of the season. On 19 May, Lichtsteiner made his 257th and final appearance for Juventus in the last match of the season in a 2–1 home win over
Verona as the club celebrated winning their seventh consecutive league title; during the same match, he missed a penalty, and was given a send-off later during the game when he came off, despite Juventus having already made all three substitutions. In this season, Lichsteiner won his seventh scudetto of his career becoming the non-Italian footballer with the most Serie A won.
Arsenal On 5 June 2018, Lichtsteiner signed for
Arsenal on a free transfer. He made his Arsenal debut on 12 August, coming on as a substitute in the 35th minute for the injured
Ainsley Maitland-Niles in an eventual 2–0 home defeat to
Manchester City. On 31 October, Lichtsteiner scored his only goal for Arsenal in the first half of a 2–1 home win over
Blackpool in the fourth round of the
2018–19 EFL Cup. On 3 June 2019, it was announced that Lichtsteiner would leave Arsenal after just one season at the club.
FC Augsburg On 19 August 2019,
Bundesliga side FC Augsburg announced the signing of Lichtsteiner on a free transfer for the
2019–20 season. He made his debut five days later in a 1–1 home draw with
1. FC Union Berlin, becoming the club's oldest ever player at 36 years and six months. On 12 August 2020, Lichtsteiner announced that he would retire from football. ==International career==