Pasquale was born in
Hershey, Pennsylvania. He attended
Bishop McDevitt High School, a Roman Catholic school in
Harrisburg, Pennsylvania. Pasquale is also a 1995
YoungArts alumnus. He attended the
Meadows School of the Arts at
Southern Methodist University as a theatre major for one semester before moving to New York, where he starred in numerous theatre productions. He originated the role of Fabrizio in the Seattle cast of
The Light in the Piazza. However, scheduling conflicts with
Rescue Me prevented him from reprising the role on Broadway, a disappointment he described as "the most heartbreaking thing that I've ever experienced professionally." He played the role of Sheriff Joe Sutter in the musical
The Spitfire Grill, where he introduced the song "Forest For the Trees." He then landed the lead role of Chris in the 1998 American tour of
Miss Saigon. In 2002, he played Robbie Faye in the New York production of
A Man of No Importance and Archibald Craven at the Joey DiPaolo AIDS Foundation's concert of
The Secret Garden alongside Michael Arden, Jaclyn Nedenthal, Will Chase, Max von Essen, Celia Keenan-Bolger, and
Tony Award-winning actress
Laura Benanti, whom he later married. In April 2009, the record label
PS Classics released Pasquale's first album, ''Somethin' Like Love,
a jazz record produced by Jessica Molaskey and John Pizzarelli. He launched his official website in February 2009 and starred in the Broadway play Reasons to Be Pretty'' by
Neil LaBute. In 2011, Pasquale played the lead role of Paul Keller on the Fox Television Studios pilot
Over/Under. The pilot was rejected in 2012 but aired on the USA Network on January 4, 2013. He also starred in the U.S. miniseries
Coma. He was the lead actor for the
NBC series
Do No Harm, which premiered on January 31, 2013, to the lowest debut rating in the history of prime-time television. In 2013, Pasquale starred in
The Bridges of Madison County at the
Williamstown Theatre Festival, alongside
Kelli O'Hara. He also starred in the Broadway production of the musical at the
Gerald Schoenfeld Theatre beginning in late January 2014, with Kelli O'Hara replacing
Elena Shaddow. He had previously worked with O'Hara in 2013, in the world premiere of
Richard Greenberg and
Scott Frankel's musical
Far from Heaven, in which he portrayed Frank Whitaker. In 2014, Pasquale guest starred in Season 6, episode 4 of the CBS legal drama series
The Good Wife. He portrayed Jonathan Elfman, campaign manager for
Alicia Florrick, who was played by
Julianna Margulies. He starred alongside
Laura Osnes in Lyric Opera of Chicago's musical
Carousel, which closed May 3, 2015. In 2016, he portrayed
Mark Fuhrman in the
FX limited series
American Crime Story: The People v. O.J. Simpson. He received the 2016
Lucille Lortel Award for Outstanding Lead Actor in a Musical for portraying Jamie Lockhart in the 2016 revival of
The Robber Bridegroom at the
Roundabout Theater Company. In 2022, he portrayed Sky Masterson opposite his wife
Phillipa Soo as Sarah Brown in the
Kennedy Center production of
Guys and Dolls. He was nominated for a
Helen Hayes Award for his performance. In 2024, Pasquale released "Some Other Time" with Center Stage Records, featuring
John Pizzarelli on jazz guitar. ==Personal life==