•
David Kaufman as Stuart Little, a young
anthropomorphic mouse adopted as part of the Little family. •
Quinton Flynn and
Kevin Schon as Snowbell, the family's
Persian cat who is Stuart's best friend. • Myles Jeffrey as George Little, the 11-year-old eldest son of the Little family and Stuart's older brother. •
Hugh Laurie as Mr. Frederick Little, the
patriarch of the Little family and Mrs. Little's husband. •
Jennifer Hale as • Mrs. Eleanor Little, the
matriarch of the Little family and Mr. Little's wife. • Martha Little, the 3-year-old infant daughter of the Little family and Stuart and George's younger sister. •
André Sogliuzzo as Monty, a gray
tabby cat who is Snowbell's best friend. •
Rachael Harris as Margalo, a young anthropomorphic
yellow canary who is Stuart's love interest. •
Pat Fraley as Falcon, a
peregrine falcon who is Stuart's nemesis. •
Jeffrey Jones as Uncle Crenshaw Little, the older brother of Mr. Little. •
Marc John Jefferies as Will Powell, George's loyal best friend. With the exceptions of Laurie, Jones, and Jefferies, none of the actors from the films reprised their roles. Daniel Hansen who previously portrayed an unnamed student in
Stuart Little 2 voices Larry Gronk. ==Episodes==