Synucleinopathy

The synucleinopathies include Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Other rare disorders, such as various neuroaxonal dystrophies, also have α-synuclein pathologies. == Signs and symptoms ==

The synucleinopathies have shared features of parkinsonism, impaired cognition, sleep disorders, and visual hallucinations. Synucleinopathies can overlap with tauopathies, possibly because of interaction between the synuclein and tau proteins. REM sleep behavior disorder (RBD) is a parasomnia in which individuals with RBD lose the paralysis of muscles (atonia) that is normal during rapid eye movement (REM) sleep, and act out their dreams or have other abnormal movements or vocalizations. Abnormal sleep behaviors may appear decades before any other symptoms, often as an early sign of a synucleinopathy. On autopsy, 94 to 98% of individuals with polysomnography-confirmed RBD are found to have a synucleinopathy—most commonly DLB or PD. Other symptoms of the specific synucleinopathy usually manifest within 15 years of the diagnosis of RBD, but may emerge up to 50 years after RBD diagnosis. From chewing to defecation, alpha-synuclein deposits affect every level of gastrointestinal function. Symptoms include upper gastrointestinal tract dysfunction such as delayed gastric emptying or lower gastrointestinal dysfunction, such as constipation and prolonged stool transit time. Urinary retention, waking at night to urinate, increased urinary frequency and urgency, and over- or underactive bladder are common in people with synucleinopathies. Sexual dysfunction usually appears early in synucleinopathies, and may include erectile dysfunction, and difficulties achieving orgasm or ejaculating. == Mechanism ==

The pathological aggregation of alpha-synuclein plays a key role in neurodegenerative disease. The misfolding and aggregation of alpha-synuclein form toxic fibrils, which in turn form pathological inclusions, such as Lewy bodies. These protein deposits are a hallmark of synucleinopathies, and may interrupt crucial neuronal processes, such as functions of synaptic vesicles, leading to neuronal death. Alpha-synuclein is encoded by the SNCA gene, and rare mutations in this gene can lead to dysfunctions of the protein structure. Post-translational modifications are also implicated in the aggregation of alpha-synuclein, mostly occurring in the C-terminus. Phosphorylation, acetylation, ubiquitination, oxidation, and other modifications alter the structure and charge of alpha-synuclein, which can in turn lead to the formation of Lewy bodies. Alpha-synuclein has a prion-like molecular spread and is suggested to be released through rare exocytosis pathways. Early synaptic and plastic alterations mediated by alpha-synuclein, as well as the mechanisms of inflammation and synaptic dysfunction that occurs before neurodegeneration, are of key interest for investigating possible therapies for synucleinpathies. ==Diagnosis==

Differential diagnosis Persons with PD are typically less caught up in their visual hallucinations than those with DLB. There is a lower incidence of tremor at rest in DLB than in PD, and signs of parkinsonism in DLB are more symmetrical. Urinary difficulties are one of the earliest symptoms with MSA, and are often severe. == Management ==

As of 2016, there are no medications that stop or improve the progression of synucleinopathies; treatments are limited to managing symptoms. Symptomatic therapies include medications for motor symptoms, treatments for autonomic dysfunction, and management of sleep or cognitive problems. Since alpha-synuclein is involved in the synucleinopathies, many potential disease-modifying treatments target this protein and its role in early inflammation and synaptic dysfunction. ==See also==