In June 1582, following the
Honnō-ji Incident which resulted in Nobunaga beings assassinated, the Iga clans rebelled again. Kitabatake Tomochika, who had been ousted during an uprising in
Ise Province fled to Iga. In response to this situation,
Oda Nobukatsu ordered his vassal who named Takigawa Katsutoshi to pacify the rebellion. However, the rebellious Iga clan attacked Kashiwara Castle again, the rebellion spread and sparking the Third Tensho Iga Rebellion.
Mitsuhiro Wada, {{Cite book | title = 天正伊賀の乱 信長を本気にさせた伊賀衆の意地 |trans-title=The Tensho Iga Rebellion: The determination of the Iga people that made Nobunaga take it seriously |language=ja The Iga forces barricaded themselves in Kashiwara Castle at Nabari District, Hijiyama Castle at Iga District, and also other castles such as the Miyata Castle, Shimabara Castle, and Amagoe Castle in Ahai. Many of Nobuyasu's vassal retreated from Iga except Ikejiri
Heizaemon-no-jo, who stubbornly held down the castle from falling to the hàn Des of the rebels. In July, Nobuyasu further sent his another's vassals, Takigawa Katsutoshi and Akiyama Ieyoshi, to subjugate rebellious Iga clans. However, they met stiff resistance, and he requested reinforcements, so Ogawa Nagayasu and others were dispatched. On August 6, the Iga forces launched a night attack, resulting in hand-to-hand combat and the defeat of the Nobuyasu forces. In September, Nobukatsu's forces decided to attack Miyata Castle. They launched an all-out attack from four directions. Nagayasu, who was in charge of one of the directions, was repelled by the Iga forces under Honda Rokuemon and Taya Jinnojō. Meanwhile, the Nagata Castle which was being defended by Nobuyasu's army still struggling against night rains mounted by the Iga forces from Hijiyama Castle, so Nagayasu was asked to take over command of the defense. Nagayasu repelled the night attacks from Hijiyama Castle, causing the Iga forces to panic and retreat from the castle. On the other place, Katsutoshi advised Nobuyasu to immediately capture the Shimabara Castle with 1,400 soldiers, including reinforcements from Takigawa Kazumasu. However, their attempt to take the castle was repulsed by the Iga forced defenders. On September 27, Taira Saemon-no-jo and Ogawa Nagayasu instead received 3,000 reinforcements from
Tsutsui Junkei from Yamato and captured Shimabara Castle in October. Later in November, Hirazaemon-no-jo suggested that Amagoi Castle would be easy to capture because it was a newly constructed castle, so Tsugawa Yukimitsu led an army to attack the castlem. However, they failed to subdue the castle. Later, Hijikata Yukihisa sent an emissary with the order to retreat as Nobukatsu went to Kyoto. Ogawa Nagayasu and Tamaru Naotake served as rear guards and repelled the pursuing force led by Hattori Densuke. Later in 1583, Nobukatsu issued a ruling stating that the Ahai District, which was already under Katsutoshi control, that he would defeat the rebel forces once the situation in the
Kamigata region had settled. However, when the
Battle of Shizugatake broke out that same year between
Hashiba Hideyoshi and
Shibata Katsuie, Nobukatsu sided with Hideyoshi. Shibata Katsuie, in a conflicting sense, contacted Yamanaka Nagatoshi, a member of the Kōka clan of Iga, to ally with the Iga clan and promote anti-Hideyoshi and Nobukatsu movements in Iga. Furthermore, Kitabatake Tomochika , who had rebelled against Nobukatsu in Ise the previous year, fled to Iga and allied with the Iga clan. Furthermore, Nobukatsu's vassals, the Akiyama and Sawa clans of Yamato , joined forces with Tomochika in a rebellion, further contributing to the unstable situation. Seishū Gunki, a military chronicle and historical book of Ise Province (1635-1636), praised Katsutoshi for his fortitude in this third campaign in Iga.{{cite book|author=Kobe Yoshimasa ==Impact==