Moodie's first television role was in the comedy
So Haunt Me in 1994, followed by a starring role as Hunter in
Neil Gaiman's 1996 fantasy mini-series
Neverwhere (1996). She featured in guest roles in various series in the 2000s, and in 2008–9 had a regular role in Irish medical drama
The Clinic. She also played the role of John Watson's therapist Ella Thompson in
Sherlock. In 2016 she played
Gertrude in
Simon Godwin's production of
Hamlet for the
Royal Shakespeare Company. From 2019, Moodie starred as Meg in the BBC television comedy series
Motherland. In a 2021 interview with the
Huffington Post, Moodie said that she was proud of the feedback she had received about her character's cancer storyline: "There's been people who have written me very personal messages saying that they're going through [cancer] right now or their parents are, and they say we've really shown what it's like. I'm really happy that that's happened – I didn't expect it to. I didn't finish filming and say 'I really feel like I've nailed what it's like to go through this journey', because it's so subjective and unique to people." In 2019, Moodie was in the
BBC Radio 4 audio drama
Forest 404. In 2020, Moodie starred in the third series of
Tin Star as Catherine Mckenzie. The series was created by
Rowan Joffé. In April 2022, Moodie featured as Regina in series 1 episode 4 of
Ten Percent. Moodie appeared in
Sam Mendes' film
Empire of Light, released in the US in December 2022, and the UK in January 2023. Moodie appears alongside
Olivia Colman,
Colin Firth and
Micheal Ward. Also in December 2022, Moodie reprised her role as Meg in the Christmas special of
Motherland, titled "Last Christmas". The episode garnered wholly positive reviews from critics. in two episodes of the
Cash Carraway-created
Rain Dogs. ==Personal life==