Racing Club Born in
Sarandí,
Greater Buenos Aires, De Paul joined
Racing Club's youth setup in 2002, aged eight. He was called up to the main squad on 24 June 2012, while still a junior, for a match against
Vélez Sarsfield, but remained unused in the 1–2 home loss. On 10 February 2013, De Paul played his first match as a professional,
replacing Mauro Camoranesi in the 86th minute of a 0–3 loss at
Atlético de Rafaela. He scored his first goal a month later, netting the last through a long-range shot in a 3–0 win at
San Martín de San Juan. De Paul appeared in 19 matches during the
2012–13 campaign. He then played a key part in
2013–14, featuring in 35 matches and scoring four times.
Valencia in 2015 On 9 May 2014, it was announced that
Valencia CF agreed to a US$6.5 million deal for De Paul with Racing. He signed a five-year deal with
Los Che on 6 June, and made his
La Liga debut on 23 August under head coach
Nuno Espírito Santo, replacing
Paco Alcácer in the 65th minute in a 1–1 away draw against
Sevilla FC, but being
sent off just one minute later due to fouling
Aleix Vidal. He scored his first goal for the club on 4 December 2014 in the 2–1 win against
Rayo Vallecano in the
Copa del Rey. He followed this up with his first La Liga goal on 9 April 2015 against
Athletic Bilbao, making 29 appearances in all competitions during his first season at the club. After making 14 appearances in all competitions during the first half of the 2015–16 season, including two in the
Champions League. On 4 February 2016, he was loaned out by then Valencia manager
Gary Neville to his former side
Racing Club. He scored his first and only goal in a victory against Bolívar on 24 February in the
Copa Libertadores.
Udinese On 20 July 2016, De Paul was transferred to Italian
Serie A club
Udinese. He made his debut on 20 August 2016 against
AS Roma in a 4–0 defeat. He scored his first goal for the club on 29 January 2017 against
AC Milan in a 2–1 victory. He started the
2018–19 season with four goals in the first six matches of the Serie A season. He would finish the season as Udinese top goal scorer with nine goals during the
2018–19 Udinese Calcio season and also nine assists. On 15 October 2019, De Paul signed a new five-year contract at Udinese. De Paul became Udinese's
club captain in December 2020, replacing
Kevin Lasagna.
Atlético Madrid in 2022 On 12 July 2021, De Paul signed a five-year contract with
Atlético Madrid. He joined his new club just days after winning the
Copa América with Argentina. On 7 December 2021, he scored his first goal for the club in a 3–1 away win against
FC Porto in the final group game of the
2021–22 UEFA Champions League.
Inter Miami On 25 July 2025, De Paul joined Major League Soccer club
Inter Miami on an initial six-month loan from
Atlético Madrid, with a mandatory purchase clause worth €15 million plus potential bonuses. He is expected to sign a four-year deal through 2029 once the move becomes permanent. A month later, on 6 August, he scored his first goal for the club in a 3–1 win over
Pumas UNAM during the
2025 Leagues Cup league phase. ==International career==