Newsome was a backup singer in a touring
Talking Heads tribute band. This later led to her being cast in
Documentary Now! in a similar role. Newsome's first major television roles were as Chelsea Leight-Leigh on
Bajillion Dollar Propertie$ and Nina on
The Comedy Get Down. She also appears as a frequent guest on podcasts such as
Comedy Bang! Bang! and
Spontaneanation with Paul F. Tompkins. Newsome is also a musician and is a member of the band Four Lost Souls alongside
Jon Langford, Bethany Thomas, and John Szymanski. The group released a debut self-titled album in 2017. Newsome was in the main cast of
Brockmire in its third season. She was also cast in the 2019
ABC pilot
Woman Up. She was cast as a lead voice in the
CBS All Access series
Star Trek: Lower Decks. She appeared in a lead role as Maj. Angela Ali in the
Netflix series
Space Force starting in 2020. Since 2020, Newsome has co-hosted
Star Trek: The Pod Directive, the official
Star Trek podcast, along with comedian
Paul F. Tompkins. ==Personal life==