In the 4th and 3rd centuries BC, the Greeks embarked on an ambitious building program for enlarging and reconstructing monumental buildings. Fame and prosperity continued throughout the Hellenistic period. In the third century BC, one Isyllus established a new procession to celebrate the birthday of Asclepius, including a new sacred hymn, which he had inscribed in the
Sanctuary of Apollo Maleatas on Kynortion hill, which was believed to be Asclepius' birthplace. During the
Achaean War in 146 BC, the Achaians converted the sanctuary into a stronghold. After
Lucius Mummius defeated the Achaians and destroyed
Corinth in 146 BC, he visited the sanctuary and left two dedications there. In 87 BC, the sanctuary was looted by the Roman general
Sulla. In 74 BC,
Marcus Antonius Creticus installed a garrison in the city, causing a lack of grain. Sometime before 67 BC the sanctuary was plundered by pirates. Archaeological evidence reveals extensive damage in the first half of the first century BC. The guest house, gymnasium, and water supply system (required for most of the sanctuary's important rituals) were abandoned and the sanctuary of Apollo Maleatas was destroyed.
Livy, in the early first century AD, speaks of how "Epidaurus ... was once rich with gifts for the god, which are now vestiges of wrecked dedications." Inscriptions claim that the town was rescued from total destruction by a series of gifts from a rich benefactor,
Euanthes son of Eunomus, who was honoured with at least six monuments. In the first century AD, the town was dominated by the wealthy Statilius and Claudius-Cornelius families, who dominated the main priestly offices, sponsored some construction work, and funded celebrations of the Apolloneia Asclapieia Caesarea Games. In the 2nd century AD the sanctuary enjoyed a new upsurge, prompted by the visit of
Hadrian to the site in 124. Hadrian introduced a range of reforms, apparently influenced by the cult of Asclepius at
Pergamum, which he was closely involved with. The priesthood of Asclepius was reformed, so that it became an annual office selected by allotment, rather than a lifetime office. The emperor reorganised the Asclepieia Games and moved their date so that they would not clash with other festival games in Greece. New cults were introduced, dedicated to "All the gods," Zeus Olympius, Zeus Panhellenius,
Telesphorus (closely associated with the Pergamene Asclepieium). Asclepius was increasingly syncretised with Zeus and with Hadrian as Zeus Asclepius
Soter (). Contemporary coinage seems to depict Hadrian and Asclepius as interchangeable. The Epidaurians honoured Hadrian with a new
era, in which documents were dated by the number of years since Hadrian's visit. In the 160s and 170s, a Roman senator from
Nysa in
Asia Minor,
Sextus Julius Major Antoninus Pythodorus donated heavily to the sanctuary, which is recorded by Pausanias (2.27.6-7), honorific inscriptions and rooftiles stamped with his name found throughout the sanctuary. His donations included a
bathhouse of Asclepius ("the north-east baths") and a temple to
Hygieia, Egyptian Asclepius, and Egyptian Apollo. He also restored the Stoa of Cotys, the sanctuary of the Epidotae ("Helping gods" such as
Machaon,
Podalirius, the "
hero doctor",
Heracles,
Tyche,
Agathos Daimon,
Nemesis,
Artemis Enodia,
Artemis Lysaea,
Pan,
Leto,
Hypnos, and
Oneiros), and the guest house. Other buildings of this period include the Library of Rufus and a small
odeon in the gymnasium for "sacred theatre." As with the reforms under Hadrian, much of this work seems to have been inspired by the sanctuary at Pergamum. Other work focussed on reviving or restoring earlier Epidaurian cults and practices. Most notably, Pythodorus carried out extensive repairs to the Sanctuary of Apollo Maleatas, which had been abandoned since the early first century BC, adding a
propylon, a
nymphaeum, and a vast subterranean cistern ("the Skanà"). These repairs allowed the procession for Asclepius' birthday, instituted by Isyllus in the third century BC, to be revived. In AD 395 the
Goths raided the sanctuary. Even after the introduction of
Christianity and the silencing of the
oracles, the sanctuary at Epidaurus was still known as late as the mid 5th century as a
Christian healing centre. ==Description==