Franklin County SR 16 begins at the
Alabama State Line in
Franklin County, on top of a very tall ridge, where it continues as
State Route 79, several miles north of
Scottsboro, AL. It continues north as a very curvy 2-lane highway before exiting the mountains and lowering down into some farmland. It then goes north to enter
Winchester at an interchange with
US 64 and
SR 15, a 4-lane bypass of Winchester, before turning east and entering downtown. In downtown, it comes to an intersection with
US 41A,
SR 50, and
SR 130. SR 16 continues east and becomes the unsigned companion route of US 41A, while also being concurrent with SR 50. US 41A/SR 16 then turn north at an intersection where SR 50 separates and continues east into
Decherd. They then have an intersection with
SR 127 before leaving Winchester. They then go north as a 2-lane highway through flat farmland before crossing the
Elk River and going through
Estill Springs, where it has an intersection with
SR 279 and passes by the
Arnold Air Force Base and the
Woods Reservoir before crossing the
Coffee County line and entering
Tullahoma.
Coffee County US 41A/SR 16 then immediately enter downtown
Tullahoma after crossing into Coffee County, where they intersect and become concurrent with
SR 55/SR 130. They then go north through downtown before SR 55/SR 130 split off and west concurrent with each other and US 41A/SR 16 then pass through a major business district before intersecting with
SR 269 and leaving Tullahoma, where it briefly crosses into
Moore County before entering
Bedford County.
Bedford County In Bedford County, US 41A/SR 16 then turn west and pass just south of
Normandy before having an intersection with
SR 276. They then enter
Shelbyville at an intersection with
SR 437, just feet before their intersection with
SR 64. US 41A/SR 16 then continue through some suburban areas and pass by an industrial park before entering downtown and having an intersection with
US 231 Business/
SR 10/
SR 82. They then have an intersection with
US 231/
SR 387 before leaving downtown and going through another suburban area before leaving Shelbyville and turning northwest. US 41A/SR 16 go northwest through some countryside and have an intersection with
SR 270 before passing through
Unionville, turning north temporarily before going northwest again. They then pass through more countryside before crossing into
Rutherford County.
Rutherford County In Rutherford County, US 41A/SR 16 then go northwest to an intersection and becoming concurrent with
SR 99 before entering
Eagleville, where they have another intersection and short concurrency with SR 269, where SR 99 splits off and goes east to follow SR 269. US 41A/SR 16 then continue through Eagleville before continuing northwest and crossing into
Williamson County.
Williamson County After crossing into Williamson County, US 41A/SR 16 then continues for a very short distance before coming to a Y-intersection with
US 31A/
SR 11 in
Kirkland, just north of
College Grove and just south of
I-840 and
Triune. At this intersection, US 41A continues north and becomes concurrent with US 31A/SR 11 while SR 16 ends here. ==Major intersections==