SR 322 begins in
Roane County in
Paint Rock at an intersection with
SR 72. It goes southeast as Sweetwater Road and traverses some ridges and valleys before curving east to enter farmland and shortly passing through the southernmost part of
Loudon County. SR 322 then crosses in
Monroe County as Oakland Road to enter
Sweetwater at an interchange with
I-75 (Exit 62). It continues east to bypass downtown to the north and have an intersection with
US 11/
SR 2. The highway then leaves Sweetwater and continues east through farmland as Sweetwater Vonore Road. SR 322 then makes a sharp right at an intersection with Loudon Road before crossing over a ridge and coming to an end at another intersection with SR 72 at the northwest corner of
Vonore. ==Major intersections==