SR 331 begins in
Knoxville at an intersection with
US 441/
SR 33 (Broadway). SR 331 goes north as Old Broadway to enter
Fountain City, where it has an interchange with
I-640/
US 25W (Exit 6) before having a partial interchange with US 441/SR 33. It then turns northeast to come to a Y-Intersection between Jacksboro Pike and Tazewell Pike, where SR 331 becomes Tazewell Pike. The highway continues northeast through suburbs before leaving Knoxville and going through farmland. SR 331 then enters
Corryton comes to an intersection with
SR 131 (E Emory Road), where SR 331 turns east onto E Emory Road while SR 131 turns north onto Tazewell Pike. SR 331 continues northeast to pass through downtown, where it has an intersection with Corryton Road, a major county Road that leads to
Plainview and
SR 144. It then leaves Corryton to continue northeast through farmland to come to an end at an intersection with
SR 61 just west of
Blaine. ==Major intersections==