SR 350 begins in
Greeneville unsigned with a concurrency with
US 11E Bus and
SR 70 at their intersection with
US 11E, it continues south where SR 70 heads south and SR 350 and US 11E Bus head east to
US 321 and
SR 107 where SR 350 heads south along US 321 and US 11E Bus heads north, it then branches off of US 321 heads more southeastward to end at
SR 351 in south central Greene County south of Greeneville and north of
Camp Creek. The entire route is in
Greene County. ==Major intersections==