Born in
Palermo, Mannino graduated in philosophy, and then she moved to
Milan, where she enrolled in the Teatro Carcano European Drama School. After several other courses and workshops, she became a stand-up comedian and began appearing in the
Canale 5 variety show
Zelig. Mannino is active on stage, in films and in many TV commercials. In 2012 she hosted a one-woman-show on
La 7,
Se stasera sono qui. In an interview, she defined the latter show as a "show talk", rather than a "talk show", meaning that the show would host characters who would hold mini-talks on aspects of society and culture. Mannino co-hosted the third night of the
Sanremo Music Festival 2024 alongside
Amadeus. ==Filmography==