A. hentzi is a rather docile and nonaggressive species. When disturbed, like most other tarantulas,
A. hentzi maneuvers itself to a stance on its hind legs and raises its front legs in a threatening manner. Additionally,
A. hentzi and most other tarantulas found in the Americas have small, coarse, brown or black
urticating hairs on their abdomens that they kick in the direction of whatever they may feel threatens them. It is the main species preyed upon by the tarantula hawk,
Pepsis grossa, in areas where the two species overlap. A. hentzi has been documented sharing their burrows with narrow-mouthed toads (
Gastrophryne spp). The toads receive protection from predators like snakes, and eat small invertebrates in the tarantula's burrow. but ignore newly hatched spiderlings. This may be a mutualism where the toads receive protection from predators and the tarantulas' spiderlings are protected from small invertebrates eaten by the toads. Bites from the Texas brown tarantula, as with all
New World tarantulas, are generally not a serious harm to humans except in the case of an
allergic reaction. Due to the large size of their fangs, the
puncture wound from a bite can also be painful and lead to
secondary infection if not properly treated. ==Distribution==