SH 152 was first designated on March 19, 1930 as the route between
Pampa and
Wheeler through northern
Gray and
Wheeler Counties as a renumbering of
SH 33A. On December 24, 1935, a highway was temporarily designated from Wheeler to the Oklahoma state line. On April 19, 1938, the extension east to Oklahoma became official. On July 15, 1938,
SH 152 Spur was designated to Old Mobeetie. On October 24, 1938,
SH 152 Spur was taken over. On September 26, 1939, the section from Dumas to Hartley was cancelled as it was cosigned with US 87. SH 152 Spur was renumbered as
Spur 41. The road to Dumas already existed, but was not fully improved until the late 1940s. ==Business route==