SH 352 begins where Parry Avenue changes into Robert B. Cullum Boulevard at 1st and 2nd Avenues, a pair of one-way streets that give the highway a connection to
I-30. SH 352 travels in a southeastern direction along Robert B. Cullum Boulevard on the southwestern edge of the
State Fair of Texas. The highway makes a sharp turn into a more direct eastern direction near 2nd Avenue, where the road name changes to Scyene Road. SH 352 crosses over
White Rock Creek and travels through a less densely populated area of the city in the
Parkdale neighborhood. Near McNeil Street, the highway turns northeast onto Scyene Circle, a newer routing of SH 352, then turns back east onto Scyene Road near Pleasant Drive; the two roads, Scyene Circle and Scyene Road, provide access between SH 352 and
Loop 12 (Bucker Boulevard). SH 352 runs through eastern Dallas then enters into
Mesquite at the intersection with Sam Houston Road. Entering Mesquite, SH 352 passes near
West Mesquite High School and
Mesquite Memorial Stadium. Just east of Peachtree Road, the highway splits into a pair of one-way streets, with eastbound traffic traveling along Military Parkway and westbound on Scyene Road. SH 352 intersects
I-635 (Lyndon B. Johnson Freeway) then travels through a less developed part of Mesquite with industrial areas until reaching Carmack Street. At Carmack Street, the eastbound round changes names to Davis Street while serving as the western terminus for Main Street, which carries westbound traffic. The highway enters Old Town Mesquite and travels through the town square where it meets Galloway Avenue and
Belt Line Road. Leaving the downtown area, SH 352 travels along the northern boundaries of
Mesquite High School and
E. H. Hanby Stadium. At Pioneer Road, the highway turns northeast while the Davis/Main Street roadway continues east as East Glen Boulevard. SH 352 travels through a rural area of Mesquite then enters
Sunnyvale near Long Creek Road. In Sunnyvale, the highway's name becomes South Collins Road and the route becomes more developed with commercial areas and restaurants. SH 352 passes Baylor Scott & White Medical Center – Sunnyvale before ending at
US 80 with the road continuing as North Collins Road. ==History==