and
Real Betis in the Round of 32. The draw for the Round of 32 was held on 14 October 2016, in
La Ciudad del Fútbol. In this round, all
La Liga teams entered the competition. Round of 32 pairings were as follows: the six remaining teams participating in the
2016–17 Segunda División B and
Tercera División faced the
2016–17 La Liga teams which qualified for European competitions. The six remaining teams participating in
Segunda División faced five
La Liga teams which did not qualify for European competitions and the remaining Europa League team from the pot 2 that was not faced with any team from the pot 1. The remaining eight La Liga teams faced each other. In matches involving teams from different league tiers, the team in the lower tier played the first leg at home. This rule will also be applied in the Round of 16, but not for the Quarter-finals and Semi-finals, in which the order of legs will be based on the luck of the draw.
Bracket ==Round of 32==