Main Cast •
Aga Muhlach as Dr. Agaton "Doc Aga" Abogado - He is a pediatrician who sought greener pastures in the United States as a nurse but returned to the Philippines after a pang of homesickness and a quest for the true meaning of life hit him.
Supporting Cast •
Nova Villa as Octavella "Tita Ocs" Flores - She is Aga's aunt who is the community's "Jill of All Trades". • Raffy De Lara as Osmundo Flores - He is Tita Ocs' husband. •
Roderick Paulate as Major Ret Retualo - He is Aga's nemesis in the neighborhood. He's a ex-military officer who stands as Tabuneknek's leader. •
Precious Lara Quigaman as Greta Retualo - She is the sister of Major Ret Retualo and the neighborhood's "Crush ng Bayan". •
Bayani Agbayani as Buddy - He is a pet shop owner in town. •
Pokwang as Cita - She is Buddy's unrequited love interest. They have an adopted pet chimp named Kokong. •
Eda Nolan as Eda - She is the town's fashionist. •
Jake Cuenca as Jake Retualo - He is the swoon-worthy son of Major Ret Retualo. • Celine Lim as Butching • Sophia Baars as Sofia • Mikan Ong as Mikan •
Jairus Aquino as Jai •
Rayver Cruz as Jai (10 years after) • Carlo Balmaceda as Bronson •
Ejay Falcon as Bronson (10 years after) ==Soundtrack==