Epidemics of many
zoonotic diseases were reported during the colonial times—particularly
smallpox. Malaria was endemic, and especially in the southern colonies everyone could be expected to become infected.
Yellow fever Yellow fever was a disease that caused thousands of deaths, and many people to flee the afflicted areas. It begins with a headache, backache, and fever making the patient extremely sick from the start, and gets its name from the yellow color of the skin, which develops in the third day of the illness. At the end of one week, the affected person is either dead or recovering. Yellow Fever made its first appearance in America in 1668, in Philadelphia, New York and Boston in 1693. It had been brought over from
Barbados.
Smallpox Smallpox is caused by the
variola virus and is extremely contagious, for it is spread by physical contact and affects children and adults alike. Smallpox was contagious, disfiguring, and often deadly. The epidemics of the disease were recurrent, devastating, and frequent. A particularly virulent sequence of smallpox outbreaks took place in
Boston, Massachusetts, where the most severe epidemic occurred. The entire population fled the city, bringing the virus to the rest of the
Thirteen Colonies. Colonists tried to prevent the spread of smallpox by isolation and
inoculation. Inoculation caused a mild form of the disease; it was new to the country and very controversial because of the threat that the procedure itself could be fatal, or otherwise spread the disease. It was introduced by
Zabdiel Boylston and
Cotton Mather in Boston in 1721. The procedure involved injecting the infection into the patient, which resulted in a mild form of the disease. This led to a shorter period a person had Smallpox than if they had contracted naturally. Strong support for inoculation came the leading Puritan minister,
Cotton Mather, who preached for inoculations during the 1721 smallpox epidemic in Boston. His advice was heeded primarily by well-educated wealthy Puritan families. The town of Cambridge and Harvard College combined broad-based inoculation programs with inspection and isolation efforts. They providing a model followed by other New England communities, which increasingly adopted the immunization and quarantine policies by 1800. South Carolina resisted inoculation. James Kilpatrick, a British physician vigorously promoted vaccination in the mid-18th century, but failed to convince local medical and political leaders. == Other colonial diseases ==